Question 1

What is Kisspeptin-10?

Accepted Answer

Kisspeptin-10 is the biologically active C-terminal decapeptide fragment of the 54-amino acid kisspeptin-54, both encoded by the KISS1 gene. It binds to the kisspeptin receptor (GPR54/KISS1R) on GnRH neurons in the hypothalamus, serving as the master regulator of the reproductive axis. Kisspeptin-10 is the most potent known stimulator of GnRH and consequently LH/FSH release. Clinical applications include diagnostic evaluation of reproductive disorders and potential therapeutic use for hypothalamic amenorrhea and IVF protocols.

Question 2

How does Kisspeptin-10 work?

Accepted Answer

Kisspeptin-10 binds GPR54 (KISS1R), a Gq-coupled GPCR on GnRH neurons. Activation triggers PLC/IP3-mediated calcium release, depolarizing GnRH neurons and stimulating pulsatile GnRH secretion. This drives LH and FSH release from anterior pituitary gonadotrophs.

Question 3

What are the research applications of Kisspeptin-10?

Accepted Answer

Reproductive endocrinology diagnostics. Hypothalamic amenorrhea treatment. IVF protocol optimization. Pubertal disorder research.

Question 4

Is Kisspeptin-10 safe for research use?

Accepted Answer

Kisspeptin-10 should only be handled by qualified researchers following proper laboratory protocols and safety guidelines.

Question 5

Where can I find research studies on Kisspeptin-10?

Accepted Answer

Scientific studies on Kisspeptin-10 can be found in peer-reviewed journals through databases like PubMed and Google Scholar.

Question 6

What quality standards should Kisspeptin-10 meet for research?

Accepted Answer

Research-grade Kisspeptin-10 should meet high purity standards, typically >95% purity, with proper analytical certification and storage requirements.

Kisspeptin-10

Research Applications

Mechanism of Action

Dosage Information

Calculation Results

Protocols

Research Studies

Kisspeptin and the Regulation of Reproduction

Related Peptides

Oxytocin

PT-141

Vasopressin

Melanotan II