Research Applications
Muscle Repair and Hypertrophy
Research demonstrates MGF is essential for muscle regeneration following damage. It activates satellite cells more potently than mature IGF-1, suggesting a unique role in the early repair phase.
Cardiac Repair
MGF expression in cardiac tissue following ischemic damage suggests cardioprotective and regenerative roles. Preclinical studies show improved cardiac function post-myocardial infarction.
Tendon and Bone Repair
MGF is expressed in damaged tendons and bone, suggesting roles in musculoskeletal tissue repair beyond muscle.
Sarcopenia
Age-related decline in MGF expression may contribute to impaired muscle regeneration in the elderly. MGF supplementation research addresses this deficit.
Mechanism of Action
MGF activates quiescent muscle satellite cells through a mechanism distinct from IGF-1R signaling. The unique C-terminal peptide engages satellite cell surface receptors (potentially through interactions with extracellular matrix components), triggering cell cycle entry and proliferation. This increases the pool of myogenic precursor cells available for muscle repair and growth. MGF also stimulates protein synthesis through the IGF-1R/PI3K/Akt/mTOR pathway via its IGF-1 domain.
Biological Pathways
Satellite cell activation through C-terminal peptide-specific signaling. IGF-1R/PI3K/Akt/mTOR for protein synthesis. MAPK/ERK for cell proliferation. Myogenic regulatory factors (MyoD, myogenin) for satellite cell differentiation.
Dosage Information
Calculation Results
Syringe Fill Level (100u syringe)
Protocols
No protocols featuring this peptide yet.
Browse All ProtocolsStability & Storage
MGF peptide is extremely sensitive to degradation in serum (half-life ~minutes). Supplied as lyophilized powder, store at -20°C. Reconstitute with bacteriostatic water, use within 14 days at 2-8°C. Must be injected locally (intramuscularly into target muscle) due to rapid systemic degradation. PEG-MGF was developed to overcome this stability limitation.
Side Effects & Precautions
Limited human safety data. Injection site pain due to intramuscular administration. Theoretical hypoglycemia risk from IGF-1 receptor activation. Potential for uncontrolled cell proliferation. Most safety data is extrapolated from IGF-1 research.
Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.
Regulatory Status
Not FDA-approved. Research compound. WADA-prohibited under S2 (Growth Factors) as an IGF-1 splice variant.
Research Studies
Mechano Growth Factor: A Splice Variant of IGF-1 for Muscle Repair
Goldspink G.
IGF-1 Splice Variants in Muscle Growth and Repair
Barton ER.
