PEG-MGF molecular structure
PEG-MGF molecular structure
Experimental
💊Muscle Building

PEG-MGF

Also known as: PEGylated MGF, PEGylated Mechano Growth Factor

MW

5000.00 Da

Routes

2 routes

PEG-MGF (PEGylated Mechano Growth Factor) is a modified version of MGF with a polyethylene glycol (PEG) chain attached to increase its biological half-life. While native MGF is rapidly degraded in the bloodstream (half-life of minutes), the PEG modification extends the half-life to several hours, enabling systemic administration and distribution to muscle tissue throughout the body rather than requiring local injection. PEGylation is a well-established pharmaceutical strategy used to extend the half-life of protein therapeutics (e.g., PEGylated interferon, PEGylated growth hormone). In the case of MGF, PEGylation trades local potency for systemic reach — PEG-MGF can be administered subcutaneously and reach multiple muscle groups, whereas native MGF must be injected directly into the target muscle.

Research Use Only— For educational and research purposes only

Research Applications

Systemic Muscle Growth

PEG-MGF enables systemic administration for whole-body muscle anabolic effects, unlike native MGF which requires local injection.

Muscle Wasting Conditions

Research for systemic treatment of sarcopenia, cachexia, and myopathies where local injection is impractical.

Recovery from Exercise

Studied for recovery from exercise-induced muscle damage through systemic satellite cell activation.

Mechanism of Action

PEG-MGF retains the core biological activities of native MGF: satellite cell activation through the C-terminal peptide and protein synthesis stimulation through IGF-1R signaling. The PEG moiety reduces renal clearance and protease degradation, extending circulation time. However, PEGylation may partially attenuate receptor binding affinity, potentially reducing acute potency compared to native MGF while providing extended duration of effect.

Biological Pathways

Same as MGF: satellite cell activation, IGF-1R/PI3K/Akt/mTOR, MAPK/ERK for proliferation. Extended pharmacokinetic profile through reduced renal clearance and protease resistance.

Dosage Information

Typical dosage ranges for research applications. Always verify with current literature.
Typical Dose
300 mcg
Dose Range
100 - 400 mcg
Frequency
2-3 times weekly, post-workout days
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Calculation Results

Concentration
2.5 mg/ml
Dose Volume
0.1 ml0.100 ml
Insulin Syringe
10 units
Doses per Vial
2020 doses @ 250 mcg

Syringe Fill Level (100u syringe)

05010010.0uunits
0u10.0 / 100 units (10%)100u

Protocols

IGF-1 LR3 + PEG-MGF Advanced Stack
Advanced
🏃Sport & Performance
6-8 weeks

Maximum muscle growth stack combining systemic IGF-1 with localized MGF for hypertrophy and repair.

Dosage
IGF-1 LR3: 50-100mcg, PEG-MGF: 200-400mcg
Frequency
IGF-1: AM or post-workout. PEG-MGF: Post-workout IM into trained muscles.
Cycle
6-8 weeks on, 4-6 weeks off
Stacking Notes
IGF-1 can be SubQ anywhere. PEG-MGF should be injected IM into muscles just trained. Rotate sites. High protein diet essential (1.2-1.5g/lb).

Warning: Very advanced protocol. Monitor blood glucose. Risk of organ growth.

View Full Protocol

Stability & Storage

PEG-MGF lyophilized powder stores at -20°C for 12-18 months. More stable than native MGF due to PEG protection. Reconstitute with bacteriostatic water, store at 2-8°C, use within 21 days. Subcutaneous injection is the preferred route (unlike native MGF which requires intramuscular).

Side Effects & Precautions

Similar profile to MGF with potential additional PEG-related effects: injection site irritation, potential anti-PEG antibody development with chronic use. Hypoglycemia risk. Limited human safety data.

Research Use Only. This information is for educational and research purposes only. Not intended for medical advice or self-medication.

Regulatory Status

Experimental

Not FDA-approved. Research compound. WADA-prohibited under S2 as an IGF-1-related growth factor.

Research Studies

PEGylation of Therapeutic Peptides and Proteins

Veronese FM, Pasut G.

Drug Discovery Today
2005
View Source

MGF and PEG-MGF in Muscle Repair

Goldspink G, Yang SY.

Journal of Molecular Endocrinology
2004
View Source
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